Cosmetic Surgery Today

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Posts Tagged ‘injectables’

Research Reveals How Skin Fillers Stimulate Collagen Production

Posted by Cosmetic Surgery Review on March 15, 2010

Demand for minimally invasive procedures including Botox, Restylane and other injectable fillers continues to be strong in the United States and abroad, even more so in the wake of the economic recession.

Soft tissue injectables are not only effective for getting rid of wrinkles, reducing the appearance of fine lines and plumping up the skin, but can also help to improve the appearance of aging and sun-damaged skin by making the skin appear more resilient and smooth.

At this year’s American Academy of Dermatology Meeting, dermatologist Dana L. Sachs, MD, FAAD, associate professor in the department of dermatology at the University of Michigan in Ann Arbor, Michigan presented findings of a study that demonstrated how certain types of hyaluronic acid dermal fillers can stimulate collagen production and help to repair the skin. These may be some of the known side effects of certain fillers, and can help some patients achieve a more youthful look after a single treatment.

Structural damage to the skin is one of the most significant effects of the aging process, and the breakdown of collagen and elastin only increases at a steady rate as the individual ages. The common effects of aging include fine lines, skin laxity and pigmentation. Advanced stages of photoaging result in coarse wrinkles, redness and discoloration of sun-exposed skin. Some types of tissue fillers may be effective at changing the skin’s structure, reducing the effects of fragmentation and helping the tissues regenerate higher levels of collagen which creates a smooth and healthy appearance.

Dr. Sachs reports, “from a clinical standpoint, dermatologists know that soft tissue fillers work by restoring volume loss and smoothing wrinkles in aging and sun-damaged skin…the biochemical study of cross-linked hyaluronic acid conducted by researchers set out to explain what takes place at the molecular level to account for the observed clinical improvements.” (Source: Medical News Today)

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Artefill May Be Effective Treatment Option for Facial Lipoatrophy

Posted by Cosmetic Surgery Review on March 2, 2010

Artefill is among the leading dermal fillers on the market to treat lines and wrinkles, and is currently available at many medical spas, cosmetic surgery centers and plastic surgery centers around the country.

The injectable was recently part of two clinical studies to determine if it would be effective as a long-term treatment for facial lipoatrophy. Results of the study were presented at the Advances in Cosmetic and Medical Dermatology’s Maui Derm 2010” meeting in Hawaii in late January, and at the American Academy of Cosmetic Dermatology Scientific Meeting in Orlando, Florida later that month.

The soft tissue filler is currently used to treat nasolabial folds, reduce lines and wrinkles around the cheeks and forehead, and can be part of a “liquid facelift” procedure. The study evaluated the efficacy of Artefill for thecorrection of lipoatrophy in HIV patients. Patients received injections over a six-month period until full correction was achieved, and were monitored shortly after the injection was administered to determine if any muscle atrophy occurred.

According to Dr. Joseph Eviatar, FACS of Chelsea Eye and Cosmetic Surgery Associates who presented at the AACS Scientific Meeting, “Artefill proved to be effective in restoring volume to the face in these HIV lipoatrophy patients and we believe may offer a more long-term, cost effective treatment option for the patient population.”

In another session presented at the Maui Derm 2010 conference, doctors reported that Artefill was effective in treating all HIV lipoatrophy patients and improvement ranged between 50 to 100 percent. Non-HIV patients also experienced a significant improvement in the overall contours of the face.

Dr. Farhad Niroomand, Associate Clinical Professor of Dermatology who presented at the Maui conference, also stated that he believes Artefill is a viable treatment option for non-surgical anti-aging enhancement, and is a viable treatment option for patients with lipoatrophy. (Source:

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Study Suggests Botox Can Prevent Migraine Pain

Posted by Cosmetic Surgery Review on March 1, 2010

Botox continues to be one of the most sought-after procedures for getting rid of fine lines and wrinkles and deep grooves in the forehead, but it also has several non-cosmetic uses. Over the years, many doctors have reached for this injectable for off-label purposes such as reducing excessive sweating, and even treating migraines. A preliminary study now suggests that botulinum injections can reduce the frequency of migraine headaches, and may be effective for treating migraine pain for the long-term.

A report published in the February issue of the Archives of Dermatology indicates that Botox injections can help to reduce the number of migraine episodes a patient receives, but may not be equally as effective for reducing the pain and pressure that many migraine sufferers experience.

Approximately 28 million Americans are affected by migraine headaches, and the pain can be severe enough to leave the sufferer severely debilitated for several hours. Researchers of the study reported very favorable outcomes when the sufferers received botulinum injections, and some reported a reduction in migraine pain approximately three months after treatment.

According to the study, migraine frequency was reduced from an average of 6.8 days per month to an average of 0.7 days per month. Patient with exploding headaches saw an average reduction in migraine frequency of 11.4 days per month to 9.4 days per month.

The authors of the study state that, “These preliminary data are intriguing, and our results provide support for the hypothesis that patients with migraine that is characterized by imploding and ocular headaches are more responsive to botulinum toxin type A than those with migraine characterized by exploding headaches…our findings invite consideration of using botulinum toxin type A injections to prevent migraine headaches and may promote the role of the dermatologist in the treatment of patients with migraine.” (Source: Archives of Dermatology)

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Cytori Receives FDA Approval for PureGraft System

Posted by Cosmetic Surgery Review on January 13, 2010

Cytori Therapeutics, Incorporated is one of several pharmaceutical and medical companies that has been experimenting with the idea of using a patient’s own fat for certain anti-aging and skin rejuvenation procedures.

Fat injections can be the best solution for some people that want to get rid of wrinkles without surgery, but there has been a lot of controversy over whether this is indeed a safe process.

Cytori has now received approval from the U.S. Food and Drug Administration to sell a device in the United States that uses a patient’s own fat for cosmetic purposes. Cytori’s PureGraft system allows a physician to harvest a patient’s fat for about 15 minutes before re-injecting it into another part of the body. This may help reduce surgery time for certain procedures, and also reduce the amount of dead cells that accompany the fat extraction process.

The PureGraft device is capable of handling both small and large volumes of fat ranging from 50ml to 250ml, and helps to keep the cells sterile before re-injection. The PureGraft system washes the graft and drains all of the tumescent fluid in the treatment site, making the entire process much safer and more efficient.

According to Marc H. Hedrick, M.D., President of Cytori Therapeutics, “FDA clearance provides us with a strategically important product in addition to the CelBrush™ to help establish our brand and build relationships with U.S. plastic and reconstructive surgeons.”

The company reports that more than 46,000 fat-grafting procedures were performed in the United States last year, and that there is now a greater demand for cosmetic procedures that require the use of a patient’s own fat cells to achieve the best possible results.

After receiving FDA approval, shares of Cytori Therapeutics, Incorporated rose 19%. The company will begin working on gaining market approval for the PureGraft system in Europe later this year, and the product will be available in the United States by the end of the first quarter of 2010.

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Woman Files Lawsuit After Getting Evolence Injections

Posted by Cosmetic Surgery Review on November 30, 2009

Mara Micevic of Oakville received Evolence injections in January 2007 from a local laser and spa clinic after the center promised she could improve her looks and achieve a more youthful appearance. Ms. Micevic states that “she didn’t think twice” about getting the injections because she had known many women who had gone to these types of clinics and had been able to improve their appearance.

However, Micevic reports that immediately after Evolence was injected into her lips, she could feel a set of “small balls” under her skin and was assured that they would disappear. Eight months later, she developed a bump under her top lip that began to ooze pus and blood. Soon after, her whole face was swollen and she got infections over her entire face.

Ms. Micevic contacted the manufacturer in 2008, she found out that Evolence was not indicated for use in the lips at all.  However, the filler had been marketed as an all-natural filler for lip augmentation in the United States and in Canada, and was made available at several medical spas and cosmetic surgery centers around the country.

Evolence is among the newest dermal fillers on the market, an injectable that promises to fill out fine lines and wrinkles instantly and produces natural-looking results. It costs approximately $500 per injection, and according to the American Society of Plastic Surgeons, Americans are spending approximately $800 million per year on injectables.

Some injectables, such as collagen fillers, do have a high risk of allergies and doctors may need to do a test before administering the entire injectable.

For Micevic, the side effects were enough to prompt a lawsuit against Johnson & Johnson and related companies who are failing to warn the public about the risk of injury, scarring, infection and disfigurement from using Evolence.  Two other women in Richmond, B.C. have also launched a notice to sue over Evolence in December 2008.

On November 3, 2009, Johnson & Johnson announced that it would discontinue the manufacture and marketing of Evolence products.

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Dermaxin Wrinkle Cream Promises Results Similar to Injectables

Posted by Cosmetic Surgery Review on November 29, 2009

Millions of men and women opt for dermal fillers and injectables such as Zyderm, Zyplast, Botox, Restylane and Juvederm to fill out lines and wrinkles, smooth out sagging skin and enhance their appearance.

The popularity of the ‘liquid facelift’ has encouraged many surgeons and aesthetic surgery professionals to sell more products that offer a quick fix for lines and wrinkles, and demand for brans including CosmoDerm, Dermalogen and Dysport has increased significantly over the past ten years.

Now, a wrinkle cream that has been deemed the world’s best topical collagen delivery system claims to offer results similar to injectables.

Dermaxin is the world’s leading anti-wrinkle cream, an all-natural collagen cream that penetrates deep into the skin within the first ten minutes after application. According to studies conducted by Dermaxin researchers, most people saw an overall reduction of wrinkles within the first 4 to 12 weeks of daily use (up to a 44% difference).

Since most injections cost between $500 to $1000 per series, Dermaxin offers a more affordable solution for getting rid of wrinkles, and does not require touchup treatments and appointments at a doctor’s office. Some people who are allergic to the toxic compounds in many injectables or those who experience burning and irritation at the injection site may be good candidates for a topical wrinkle treatment instead.

According to Dermaix spokesperson Teresa Richards, “Dermaxin uses is the most powerful delivery system in the world – Hyaluronic Acid – to penetrate the folds of the ski and supply collagen to the deep dermal layers…the same instantaneous wrinkle-busting and smoothing effect found with injections is also achieved –within the first ten minutes of using the product – thanks to the power of Acetyl Hexapeptide08, a proven facial-relaxing compound and wrinkle remover that provides results similar to those of Botox, but without any of the associated risks.” (Source: Dermaxin Press Release)

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Lidocaine with Dermal Fillers Improves Recovery

Posted by Cosmetic Surgery Review on November 12, 2009

j0182629Millions of men and women seek wrinkle reduction with the use of dermal fillers or injectables, a set of injections that can make the skin appear smoother and more youthful immediately after treatment.

Fillers such as Restylane, Juvederm and Botox can decrease lines and wrinkles while smoothing out and sculpting the face. Now, researchers are finding that when the injections are mixed with a certain amount of lidocaine, the patient experiences less swelling and pain from the procedure, and also spends less time in the office waiting for the anesthesia to take effect.

Plastic surgeons at UT Southwestern medical Center have outlined this innovative technique in the October issue of Plastic and Reconstructive Surgery, indicating that lidocaine in the fillers will instantly minimize pain and make it easier on the patient. The addition of lidocaine also means a shorter recovery time.

According to Dr. Rod Rohric, chairman of plastic surgery at UT Southwestern, the technique involves mixing 2 percent lidocaine with hyaluronic acid and other fillers to create a numbing effect while the injectable is administered into the skin. Dr. Rohric also points out that the addition of lidocaine is becoming more standard with the emergence of fillers such as Hydrelle and Prevelle which already have lidocaine in their list of ingredients.

Demand for minimally invasive procedures such as Restylane, Botox and Hydrelle continue to rise as more men and women seek alternatives to surgery in order to preserve their youthful appearance. Adding a certain concentration of lidocaine to the injectable may help the surgeon minimize the pain and swelling commonly associated with the procedure, and this may make the entire treatment more attractive to people who have refrained from undergoing the pain and discomfort associated with treatment.

More information about injectable fillers as an anti-aging treatment can be found here.

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Demand for Dermal Fillers Remains Strong Despite State of the Economy

Posted by Cosmetic Surgery Review on September 9, 2009

42-15717262While many prospective patients are waiting for a better economic climate before forking over a few hundred dollars for plastic surgery, those in need of a quick fix are still heading to the cosmetic surgeon’s office for a more affordable treatment. Demand for dermal fillers remains strong in these turbulent times, and the Center for Cosmetic and Plastic Surgery in San Diego reports a 30% increase in requests for dermal fillers this year.

The American Society of Plastic Surgeons (ASPS) had previously issued a report about demand for injectables this Spring, concluding that many people would still be seeking out alternatives to pricey surgery. The statistics from the Center for Cosmetic and Plastic Surgery confirms that this has been the case for the latter half of 2009.

Some of the most sought-after injectables include Botox, Artefill,  and Restylane. Hyaluronic acid fillers are most commonly used for treating fine lines and wrinkles around the face, while Botox is most commonly used to fill out deep grooves on the forehead. Artefill is among the longer-lasting fillers that is commonly used to treat smile lines and fill the lips. Various collagen and hyaluronic acid dermal fillers have been approved by the FDA for the correction of lines and wrinkles, and some doctors also use them in conjunction with other skin rejuvenation treatments to enhance results.

Most dermal fillers take between 15 to 30 minutes to administer, and typically deliver immediate results with no downtime. This makes them a convenient option for many men and women on the go, and the lower price points – anything from $300 to $600+ per treatment – also make this an affordable choice for many during these tough economic times.

Dr. Alavi, the medical director at the Center for Cosmetic and Plastic Surgery, points out that injectables like Artefill also last approximately six months, so patients can make an investment now and enjoy several immediate, short-term benefits.

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Initial Aquamid Wrinkle Filler Trials Proving to Be a Success

Posted by Cosmetic Surgery Review on March 16, 2009

aquamidInjectable fillers continue to be an affordable and safe anti-aging treatment for many people looking for a quick-fix for treating wrinkles, enhancing the lips or balancing out the nose. While dermal fillers such as Botox, Restylane and Juvederm are among the most sought-after injectables in today’s non-surgical market, researchers are testing many other compounds so that patients have even more options in the near future.

Aquamid wrinkle fillers have been undergoing trials and testing for several years, and are finally appearing in select cosmetic surgery centers and medical spas around the world. Dr. Rhonda Narins, a dermatologist in New York recently reported on the results of her participation in a study of Aquamid. The 30 patients in her trial project did not experience any problems with the injectable, and did enjoy immediate results. (Source:

Aquamid is a transparent injectable that can be used for lip augmentation, smoothing out nasolabial folds, getting rid of deep wrinkles, and even as part of a rhinoplasty procedure. The injectable is physically and chemically stable, and very soft and malleable. Individuals who are allergic to some of other compounds present in today’s leading dermal fillers may be good candidates for this injectable that promises easy administration and no allergic reactions.

In addition to filling out lines and wrinkles, Aquamid can be used to contour the face; surgeons have used it to sculpt high cheekbones, enhance the lips and create more contours around the face for a more sculpted, youthful appearance. Results are immediate, and the filler does not degrade over time; according to the company website, Aquamid provides aesthetic satisfaction for years after the first treatment; It restores facial volume for the long-term, providing natural, lasting results.

According to Contura International, the company that makes Aquamid, the injectable has been used in over 40 countries. It is not yet available in the United States, and may still need to undergo thorough FDA review and trials before reaching the U.S. cosmetic surgery market.

Posted in Antiaging, botox alternatives | Tagged: , , , , | 1 Comment »

Belotero for Wrinkle Reduction Reaches Phase III Clinical Trials in U.S.

Posted by Cosmetic Surgery Review on February 3, 2009

checklistWhile millions of Americans continue to enjoy their Botox fix to get rid of wrinkles and freshen up their looks, a number of Botox alternatives may soon become available and offer more options.

Clinical trials of treatments such as PurTox, Reloxin and Belotero are underway which means there may be more affordable and even more effective treatments available for the mainstream market.

Belotero has already received approval for use in Europe and has reached Phase III of clinical trials in the United States.  This injectable also helps to eliminate fine lines and wrinkles, smooths out the skin and promises few side effects. Results are expected to last between 4 to 9 months, which means patients can enjoy fewer touch up  treatments over the course of the year.

Tina Alster, M.D., Director of the Washington Institute of Dermatologic Laser Surgery in Washington and clinical professor of dermatology at Georgetown University Medical Center explains that having more options for wrinkle removal and several alternatives to Botox helps both the patient and the surgeon.

She states that;  “competition allows us to raise the bar and also enables practitioners to fine-tune the treatment plan for different individals…the more products you have available, the better, because you’re treating a wide variety of body sites, skin types and skin conditions.  It’s not just that we’re plumping wrinkles.” (Source: Cosmetic Surgery Times)

Belotero works in a similar way as Botox, relaxing and paralyzing the facial muscles so that wrinkles become less noticeable, and as long as the patient keeps up with treatments, prevents the formation of future wrinkles.

If the injectable proves satisfactory in the Phase III trials, it may be marketed with the status of FDA approval and will be monitored extensively as consumers begin to use it.  If any adverse effects are reported during this period, the drug would be pulled from the market. So far, adverse effects of Belotero have been infections of the injection site. However, this may be prevented with the right equipment and protocol.

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